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Have you got any experience? zoloft 75 mg nsw In the last 22 years widespread prostate-specific antigen (PSA) screening has led to more prostate cancer diagnoses, but \"the proportion of high Gleason score disease did not change drastically,\" said lead researcher Kathryn Penney, an instructor in medicine at Harvard Medical School in Boston. \"This suggests that Gleason does not progress to a higher grade over time,\" she said.